業績目録（筆頭著者のアレルギー関連英語論文のみ記載）

総説

1.      Shirasaki H. Cysteinyl leukotriene receptor CysLT1 as a novel therapeutic target for allergic rhinitis. Expert Opin Ther Targets 2008;12: 415-423.

2.      Shirasaki H, Himi T. Role of cysteinyl leukotriene receptor antagonists in the management of allergic rhinitis. Clin Exp Allergy Reviews 2008;8: 50-52.

3.       Shirasaki H. Allergic Rhinitis Medications. Int J Aller Medications 2015;1:002e.

4.      Shirasaki H, Himi T. Role of cysteineyl leukotrienes in allergic rhinitis. Adv Otorhinolaryngol 2016;77:40-45.

5.      Shirasaki H, Saikawa E, Seki N, Kikuchi M, Himi T. Nasal mucosal expression of the receptors for inflammatory chemical mediators. Adv Otorhinolaryngol 2016;77:52-58.

 

原著論文

6.      Shirasaki H, Kojima T, Asakura K, Kataura A, Shimamoto K, Iimura O. The pathophysiological role of kinin and chemical mediators on experimental allergic rhinitis. Adv Exp Med Biol 1989; 247A:375-378.

7.       Shirasaki H, Asakura K, Sohma S, Kataura A. Inhibitory effects of azelastine on nasal allergic responses in sensitized guinea pigs. Eur Arch Otorhinolaryngol 1992; 249:279-282.

8.      Shirasaki H, Asakura K, Kojima T, Sohma S, Kataura A. The role of histamine, leukotriene C4 and bradykinin on nasal vascular permeability in experimental nasal allergy of guinea pigs. Rhinology 1992; 30:41-48.

9.      Shirasaki H, Nishikawa M, Adocock IM, Mak JC, Sakamoto T, Shimizu T, Barnes PJ. Expression of platelet-activating factor receptor mRNA in human and guinea pig lung. Am J Respir Cell Mol Biol 1994;10:533-557.

10.   Shirasaki H,Adcock IM, Kwon OJ, Nishikawa M, Mak JC, Barnes PJ. Agonist-induced up-regulation of platelet-activating factor receptor messenger RNA in human monocytes. Eur J Pharmacol 1994; 268:263-266.

11.    Shirasaki H, Asakura K, Narita S, Watanabe M, Kataura A. The effects of NK1 receptor antagonists (FK224 and FK888) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. Inflamm Res 1997, 46:28-31.

12.   Shirasaki H, Asakura K, Narita S, Kataura A. The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. Rhinology 1998, 36:62-6.

13.   Shirasaki H, Asakura K, Narita S, Kataura A. Expression of substance P (NK1) receptor mRNA in human nose. Acta Otolaryngol 1998, 118:717-722

14.   Shirasaki H, Watanabe K, Kanaizumi E, Kataura A. Analysis of apoptotic cells in human nose. Rhinology 1999; supplement 15 :113-114.

15.   Shirasaki H, Watanabe K, Kanaizumi E, Sato J, Matsui T, Narita S, Kataura A, Himi T. Analysis of apoptotic cells in allergic and non-allergic nasal mucosa. Allergol Int 2001;50:258-265.

16.   Shirasaki H, Kanaizumi E, Watanabe K, Matui T, Sato J, Rautiainen M, Himi T. Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. Clin Exp Allergy 2002; 32:1007-1012.

17.    Shirasaki H, Kanaizumi E, Watanabe K, Konno N, Sato J, Narita S, Himi T. Tumor necrosis factor increases MUC1 mRNA in cultured human nasal epithelial cell. Acta Otolaryngol (Stockh) 2003;123:524-531.

18.   Shirasaki H,Kanaizumi E, Watanabe K, Konno N, Sato J, Asakura K, Kataura A, Himi T. Expression of neurokinin A (NK2) receptor mRNA in human nasal mucosa Acta Otolaryngol (Stockh) 2004;124(Suppl 553):85-89.

19.    Shirasaki H, Watanabe K, Kanaizumi E, Konno N, Sato J, Narita S, Himi TExpression and localization of steroid receptors in human nasal mucosa Acta Otolaryngol (Stockh) 2004; 124:958-963.

20.   Shirasaki H, Watanabe K, Kanaizumi E, Sato J, Konno N, Narita S, Himi T. Effect of glucocorticosteroids on tumor necrosis factor—induced intercellular adhesion molecule-1 expression in cultured primary human nasal epithelial cells. Clin Exp Allergy 2004;34; 945-951.

21.   Shirasaki H, Watanabe K, Kanaizumi E, Sato J, Konno N, Narita S, Himi T.　Effects of cetirizine on substance P release in patients with perennial allergic rhinitis. Ann Otol Rhinol Laryngol 2004;113:941-945.

22.   Shirasaki H, Seki N, Kikuchi M, Kanaizumi E, Watanabe K, Konno N, Himi T. Expression and localization of the platelet activating factor (PAF) receptor in human nasal mucosa. Ann Allergy Asthma Immunol 2005;95:190-196.

23.    Shirasaki H, Kanaizumi E, Seki N, Kikuchi M, Watanabe K, Konno N, Himi T. Distribution of specific binding sites for cysteinyl leukotriene 1 receptor antagonist in human nasal mucosa. Acta Otolaryngol (Stockh) 2006; 126: 948-951.

24.    Shirasaki H, Seki N, Fujita M, Kikuchi M, Kanaizumi E, Watanabe K, Himi T. Agonist- and Th2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes. Ann Allergy Asthma Immunol 2007; 99:340-347.

25.    Shirasaki H, Kikuchi M, Seki N, Kanaizumi E, Watanabe K, Himi T. Expression and localization of the thromboxane A2 receptor in human nasal mucosa. Prostaglandins Leukot Essent Fatty Acids 2007;76; 315-320.

26.   Shirasaki H, Yamamoto T, Koyanagi Y, Watanabe N, Himi T. Detection of Specific IgEAntibodies in Sera of Japanese Birch-Allergic Patients Using Recombinant Allergens Bet v 1, Bet v 2 and Bet v 4.Allergol Int 2008;57:93-96.

27.    Shirasaki H, Kikuchi M, Kanaizumi E, Himi T. Accumulation of CRTH2-positive leukocytes in human allergic nasal mucosa. Ann Allergy Asthma Immunol 102:110-115,2009.

28.    Shirasaki H,Kanaizumi E, Himi T. Immunohistochemical localization of the bradykinin B1 and B2 receptors in human nasal mucosa. Mediators Inflammation. volume 2009, article ID 102406, 6 pages, 2009.

29.   Shirasaki H, Kanaizumi E, Seki N, Himi T. Correlation of local FOXP3-expressing T cells and Th1-Th2 balance in perennial allergic nasal. International Journal of Otolaryngology Volume 2011 Article ID 259867, 6 pages, 2011

30.    Shirasaki H, Kanaizumi E, Himi T. Anti-leukotriene therapy may be effective for the treatment of salivary eosinophilic inflammation. Allergol Int2012;61: 175-176.

31.    Shirasaki H,Kanaizumi E, Seki N, Himi T. Localization and up-regulation of the nasal histamine H1 receptor in perennial allergic rhinitis. Mediators Inflammation. volume 2012, article ID 951316, 6 pages, 2012.

32.    Shirasaki H, Kanaizumi E, Seki N, Fujita M, Kikuchi M, Himi T. Localization and up-regulation of cysteinyl leukotriene-2 receptor in human allergic nasal mucosa. Allergol Int2013; 62: 223-228.

33.    Shirasaki H, Kanaizumi E, Seki N, Kikuchi M, Himi T. Expression and localization ofpurinergic P2Y12 receptor in human nasal mucosa. Allergol Int2013;62: 239-244.

34.    Shirasaki H, Kanaizumi E, Seki N, Himi T. Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells. Allergol Int2015; 64:169-174.

35.    Shirasaki H, Kanaizumi E, Himi T. Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbine. Auris Nasus Larynx 2016; 43 : 309 - 314.

36.    Shirasaki H, Kanaizumi E, Himi T.Expression and localization of GPR99 in human nasal mucosa. Auris Nasus Larynx 2017;44: 162- 167. 

37.   Shirasaki H, Yamamoto T, Abe S, Kanaizumi E, Kikuchi m, Himi T. Clinical benefit ofcomponent-resolved diagnosis in Japanese birch-allergic patients with a convinceing history of apple or peach allergy. Auris Nasus Larynx 2017;44: 442- 446.

38. Shirasaki H, Kanaizumi E, Himi T. Leukotriene D4 induces chemotaxis in human eosinophilic cell line, EoL-1 cells via CysLT1 receptor

　　activation. Heliyon 2017;3: e00464.